human 3-d tissue models in radiation biology: current status and future perspectives

نویسندگان

a. acheva stuk - radiation and nuclear safety authority, laippatie 4, 00880 helsinki, finland

a. aerts sck•cen - belgian nuclear research centre, radiobiology unit, boeretang 200, b-2400 mol, belgium

ch. rombouts sck•cen - belgian nuclear research centre, radiobiology unit, boeretang 200, b-2400 mol, belgium

s. baatout sck•cen - belgian nuclear research centre, radiobiology unit, boeretang 200, b-2400 mol, belgium

چکیده

in this review, we discuss the use of a variety of 3-d models (particularly 3-d skin, lung, breast and endothelial) in radiobiological research and highlight the differences in responses compared to 2-d culturing conditions (monolayers). we review the characteristics of existing 3-d models and aim to point out the substantial advantages 3-d cultures provide for modern radiobiology. in particular, they may facilitate the shift from the classical dna damage and repair studies mainly carried out in monolayer cultures to the investigation of more generalized responses through pathway analysis and a system biology approach. 3-d models are expected to be very informative for investigations on radiotherapy responses in addressing the low dose risk. however, the 3-d model systems are not as easy to propagate and standardize as monolayer cultures. therefore, we discuss the problems and limitations of 3-d models and propose ways to overcome some of the problems.

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Human 3-D tissue models in radiation biology: current status and future perspectives

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عنوان ژورنال:
iranian journal of radiation research

جلد ۱۲، شماره ۲، صفحات ۸۱-۹۸

کلمات کلیدی
[ 3 , ' d t i s s u e m o d e l s ' , ' r a d i a t i o n b i o l o g y ' ]

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